Systems-based approaches to cardiovascular disease
نویسندگان
چکیده
منابع مشابه
Cardiovascular networks: systems-based approaches to cardiovascular disease.
Traditional biological and biochemical studies deal with relatively few components, allowing intuitive reasoning to guide hypotheses and experiments. For example, a popular experimental protocol in cardiovascular research is to examine gene functions through the use of transgenic or genetargeted mice. Although clearly informative, it is becoming increasingly clear that such studies alone are no...
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Abstract—The genetic architecture underlying the heritability of cardiovascular disease is incompletely understood. Metabolomics is an emerging technology platform that has shown early success in identifying biomarkers and mechanisms of common chronic diseases. Integration of metabolomics, genetics, and other omics platforms in a systems biology approach holds potential for elucidating novel ge...
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The pace of discovery of cardiovascular biomarkers seems to be slowing. Although important advances in the identification of molecular biomarkers have been made during the past decade, it is becoming apparent that their clinical relevance is limited and that advanced discovery methods are needed. There are 27 000 articles on cardiac biomarkers in PubMed. However, only a small number of these bi...
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Cardiovascular disease Barbara Howard (Hyattsville, MD) gave the Kelley West lecture, in which she discussed the Strong Heart Study and the relationship between diabetes and cardiovascular disease (CVD). The study, which began in 1988 in three American Indian communities, describes “the epidemic of CVD and diabetes among this population.” A total of 4,549 individuals age 45–74 years of age livi...
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Proteins play a central role in a systems view of biologic processes. This review provides an overview of proteomics from a systems perspective. We survey the key tools and methodologies used, present examples of how these are currently being used in the systems biology context, and discuss future directions.
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2012
ISSN: 1759-5002,1759-5010
DOI: 10.1038/nrcardio.2011.208